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CompletedEarly Phase 1

Neuronal Correlates of Altered States of Consciousness

NCT02308969 · 5HT2A-fMRI · University Hospital, Basel, Switzerland

Closed to entry
Status
Not accepting participants
Early Phase 1
Phase
24
Target enrolment
1
Study sites
Outside the US

What it is testing

Summary

The aim of the present study is to assess the neuronal correlates of alterations in waking consciousness pharmacologically induced by a 5-hydroxytryptamine (HT)2A receptor agonist in healthy subjects using functional magnetic resonance imaging (fMRI).

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

  • fMRI brain activity

    Measured over 1 hour

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

25 Years to 65 Years
Ages
All
Sex
Accepted
Healthy volunteers
Inclusion Criteria: 1. Age between 25 and 65 years 2. Understanding of the German language 3. Understanding the procedures and the risks associated with the study 4. Participants must be willing to adhere to the protocol and sign the consent form 5. Participants must be willing to refrain from taking illicit psychoactive substances during the study. 6. Participants must be willing to drink only alcohol-free liquids and no xanthine-containing liquids (such as coffee, black or green tea, red bull, chocolate) after midnight of the evening before the study session, as well as during the study day. 7. Women of childbearing potential must have a negative pregnancy test at the beginning of the study and before each study session. Exclusion Criteria: 1. Chronic or acute medical condition 2. Current or previous major psychiatric disorder 3. Psychotic disorder in first-degree relatives 4. Illicit substance use (except tetrahydrocannabinol (THC)-containing products) more than 10 times or any time within the previous month. 5. Pregnant or nursing women. 6. Participation in another clinical trial (currently or within the last 30 days)

Where

1 study site

FacilityCityRegionCountry
University HospitalBaselSwitzerland

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT02308969 on ClinicalTrials.gov →

Last updated in the registry 2015-09-25. Registry records change; this page reflects the data build of 2026-08-25.

Related

Where this trial sits