Unknown statusPhase 1 / Phase 2

The Effect of LSD on Neural Synchrony, Prosocial Behavior, and Relationship Quality

NCT05670184 · Maastricht University

Closed to entry

Status

Not accepting participants

Phase 1 / Phase 2

Phase

Target enrolment

Study sites

Outside the US

What it is testing

Summary

The goal of this study is to assess the effects of LSD on neural synchrony, prosocial behavior, and relationship quality in healthy romantic couples.

Summary as written by the trial’s own sponsor and published on ClinicalTrials.gov API v2. It is the sponsor’s description, reproduced unedited, not an assessment by this site.

What counts as success

Primary outcome measures

Neural synchrony
Measured over On the acute dosing test day, 1.5-2 hours after substance administration

A trial succeeds or fails on its primary outcome, declared in advance. Everything else it reports is secondary by definition.

Who can take part

Eligibility, as published

18 Years to 35 Years

Ages

All

Sex

Accepted

Healthy volunteers

Inclusion Criteria: * Written Informed Consent * Understanding the procedures and the risks associated with the study. * Age between 18 and 35 years old. * Being in a steady relationship for at least 6 months. * Proficient knowledge of the English language * Previous experience with at least one psychedelic drug (psilocybin, LSD, mescaline, Ayahuasca, DMT, 5-MeO-DMT), but not within the past 3 months * Absence of any major medical condition as determined by medical examination and laboratory analysis * Absence of any major psychological condition as determined by medical examination * Free from psychotropic medication * Participants must be willing to refrain from taking illicit psychoactive substances during the study. * Participants must be willing to drink only alcohol-free liquids and no coffee, black or green tea, or energy drink after midnight of the evening before the study session, as well as during the study day. * Participants must be willing not to drive a traffic vehicle or to operate machines within 24 h after substance administration. * Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2 Exclusion Criteria: * History of drug addiction (determined by the medical questionnaire, drug questionnaire and medical examination) * Previous experience of serious side effects to psychedelic drugs (anxiety or panic attacks) * Pregnancy or lactation * Hypertension (diastolic \> 90 mmHg; systolic \> 140 mmHg) * Current or history of psychiatric disorder (determined by the medical questionnaire and medical examination) * Psychotic disorder in first-degree relatives * Any chronic or acute medical condition * History of cardiac dysfunctions (arrhythmia, ischemic heart disease,…) * For women: no use of a reliable contraceptive * Tobacco smoking (\>20 per day) * Excessive drinking (\>20 alcoholic consumptions per week) * Experience with a full dose of a psychedelic within the last three months * Current use of SSRI medication

Where

1 study site

Facility	City	Region	Country
Maastricht University	Maastricht	—	Netherlands

On the registry

Contact the trial directly

This site does not enrol anyone and is not involved in this trial. To ask about taking part, use the sponsor’s own contact details on the official registry record, which is also where the most current version of everything above lives.

Before you do, the preparation checklist lists what a site will ask you on a first call and what is worth asking them. It is free and collects nothing.

NCT05670184 on ClinicalTrials.gov →

Last updated in the registry 2023-01-04. Registry records change; this page reflects the data build of 2026-08-25.

Where this trial sits

Substance

All 2 trials from Maastricht University →