Indication
Severe Depression
6 registered trials testing Psilocybin, Ketamine for this indication, 2 recruiting now.
Sponsors register this under 2 different names, all collected here: Depression Severe · Severe Depression
6
Registered trials
2
Recruiting
2
In Phase 3
Substances tested
Being studied with
Stay told
When a new trial opens
Trials
All 6 trials for Severe Depression
| Trial | Status | Phase | Substance | Sites |
|---|---|---|---|---|
| Nebulized Ketamine for the Treatment of Major Depressive DisorderNCT06752759 · Theresa Jacob, PhD, MPH | Recruiting | Phase 3 | ketamine | 1 |
| At-Home tDCS as Maintenance TherapyNCT07269964 · Technical University of Munich | Recruiting | Not applicable | ketamine | 2 |
| Effectiveness of Ketamine for Depression and Suicidal Ideation in the Emergency DepartmentNCT04266288 · MercyOne Des Moines Medical Center | Completed | Phase 4 | ketamine | 1 |
| Initiating Ketamine in Acutely Suicidal Patients in the Emergency DepartmentNCT04260607 · Naval Medical Center Camp Lejeune | Terminated | Phase 3 | ketamine | 1 |
| Psilocybin and DepressionNCT03380442 · University of Helsinki | Unknown status | Phase 2 | psilocybin, ketamine | — |
| Administration of Subanesthetic Dose of Ketamine and Electroconvulsive Treatment for Treatment Resistant DepressionNCT02522377 · The Cleveland Clinic | Completed | Not applicable | ketamine | 1 |
Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.