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Academic or other sponsor

Massachusetts General Hospital

17 registered trials on this registry, 2 recruiting now. An academic sponsor is usually answering a scientific question rather than seeking approval, which changes what its trials are designed to show.

17
Registered trials
2
Recruiting
1
In Phase 3
8
With results posted

Working on

Substances

Trials

All 17 trials

TrialStatusPhaseSubstanceSites
Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With DepressionNCT05450432 · Massachusetts General HospitalRecruitingPhase 4ketamine1
Coaching as an Adjunct to Ketamine Therapy for Treatment-Resistant DepressionNCT07563868 · Massachusetts General HospitalRecruitingNot applicableketamine2
A Study of Brexpiprazole Plus Ketamine in Treatment-Resistant Depression (TRD)NCT03149991 · Massachusetts General HospitalCompletedPhase 4ketamine6
Ketamine for Depression: An MRI StudyNCT02544607 · Massachusetts General HospitalCompletedPhase 4ketamine1
N-methyl-D-aspartate Antagonist (Ketamine) Augmentation of Electroconvulsive Treatment for Severe Major DepressionNCT01260649 · Massachusetts General HospitalTerminatedPhase 4ketamine1
Intranasal Ketamine for Late-Life Depression and Suicidal IdeationNCT02295787 · Massachusetts General HospitalWithdrawnPhase 4ketamine—
The Impact of Ketamine on the Reward Circuitry of Suicidal PatientsNCT02532153 · Massachusetts General HospitalWithdrawnPhase 3ketamine1
The Effects of Psilocybin on Self-Focus and Self-Related Processing in Treatment Resistant MDDNCT05381974 · Massachusetts General HospitalWithdrawnPhase 2psilocybin1
Double-Blind, Placebo-Controlled Trial of Ketamine Therapy in Treatment-Resistant Depression (TRD)NCT01920555 · Massachusetts General HospitalCompletedPhase 2ketamine6
Integrating Ketamine Effects on Neuronal Molecular Signatures and the Brain Functional and Structural ConnectomeNCT06698848 · Massachusetts General HospitalActive, not recruitingPhase 1ketamine1
Biomarker Discovery for Suicide Precision Circuit TherapeuticsNCT07723066 · Massachusetts General HospitalNot yet recruitingN/Aketamine—
The Effects of Ketamine on Respiratory Stimulation and Transpulmonary PressuresNCT01969227 · Massachusetts General HospitalCompletedNot applicableketamine2
Neurocognitive Features of Patients With Treatment-Resistant DepressionNCT03134066 · Massachusetts General HospitalCompletedN/Aketamine—
Physiological and Cognitive Biomarkers for Ketamine's Antidepressant EffectsNCT02669043 · Massachusetts General HospitalTerminatedNot applicableketamine1
Ketamine and Scopolamine Infusions for Treatment-resistant Major Depressive DisorderNCT01613820 · Massachusetts General HospitalWithdrawnNot applicableketamine1
Ketamine Infusion for Treatment-resistant Major Depressive DisorderNCT01582945 · Massachusetts General HospitalCompletedNot applicableketamine1
Ketamine Versus Placebo for Treatment Resistant Major Depressive DisorderNCT01667926 · Massachusetts General HospitalCompletedNot applicableketamine1

Sponsor attribution is the lead sponsor recorded on ClinicalTrials.gov API v2. Collaborators are not counted here. Data build 2026-08-25.