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Indication

Major Depression Severe

3 registered trials testing LSD, Ketamine, DMT for this indication, none currently recruiting.

3
Registered trials
0
Recruiting
0
In Phase 3

Substances tested

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This registry is rebuilt every day. If no trial is recruiting for you today, that can change within weeks.

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Trials

All 3 trials for Major Depression Severe

TrialStatusPhaseSubstanceSites
Ayahuasca and Esketamine for Major DepressionNCT07212946 · University of Sao PauloCompletedPhase 2ketamine, dmt1
Shortened LSD Intervention for Major Depressive DisorderNCT07503002 · Johns Hopkins UniversityNot yet recruitingPhase 1lsd1
Oral and Sublingual KetamineNCT07683988 · Western University, CanadaNot yet recruitingPhase 1ketamine—

Records from ClinicalTrials.gov API v2, data build 2026-08-25. Indications are the sponsors’ own words. LSD.com reports registered clinical research. It is not medical advice, it is not a recommendation to take any substance, and trial listings are not endorsements. Talk to a clinician.